The most common side effects of GLP-1 medications, including Wegovy, Ozempic, Mounjaro, Zepbound, and Rybelsus, are primarily digestive and often improve as your body adjusts:
- Nausea (most common, especially when starting or increasing your dose)
- Diarrhea
- Vomiting
- Constipation
- Stomach discomfort or bloating
Starting at a low dose and gradually increasing (dose escalation) helps most people tolerate these effects much better. This is why GLP-1 medications are started at the lowest dose and increased slowly over weeks.
When to contact your clinician:
- If side effects feel severe or are preventing you from eating or drinking
- If you experience sharp abdominal pain (possible sign of pancreatitis, rare but requires immediate attention)
- If you develop a fast heartbeat or unusual symptoms
For the complete safety profile of your specific medication, visit:
- Wegovy / Ozempic (semaglutide): wegovy.com / ozempic.com
- Mounjaro / Zepbound (tirzepatide): mounjaro.lilly.com
- Rybelsus: rybelsus.com
What are the side effects of GLP-1 weight loss medications?
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